Synthesis, Characterization and structure-activity relationship of a novel pregabalin cocrystals with sustained-release performance

Key Points

• The aim is to develop and evaluate pregabalin co-crystals to enhance drug release and pharmacological performance.
• Employed crystal engineering strategies for co-crystal synthesis
• Characterized co-crystal structures and properties
• Assessed sustained-release performance through in vitro testing
• Developed novel pregabalin co-crystals with improved release profiles
• Showed significant enhancement in drug stability and bioavailability
• Demonstrated prolonged analgesic effects compared to standard pregabalin