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Synapse
March 19, 2026CrystEngComm

Synthesis, Characterization and structure-activity relationship of a novel pregabalin cocrystals with sustained-release performance

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Authors

JRJiaxuan RenDWDi WuYFYaoguang Feng

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Overview

Demonstrates the enhanced sustained-release of pregabalin co-crystals in drug formulation, suggesting improved management of neuropathic pain.

Key Points

  • The aim is to develop and evaluate pregabalin co-crystals to enhance drug release and pharmacological performance.
  • Employed crystal engineering strategies for co-crystal synthesis
  • Characterized co-crystal structures and properties
  • Assessed sustained-release performance through in vitro testing
  • Developed novel pregabalin co-crystals with improved release profiles
  • Showed significant enhancement in drug stability and bioavailability
  • Demonstrated prolonged analgesic effects compared to standard pregabalin

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/69bb92be496e729e62980449https://doi.org/10.1039/d6ce00023a
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