A Supramolecular Protein–Silver Nanoparticle Composite Hydrogel with Efficient Antibacterial Activity and Enhanced Wound Healing Performance

Key Points

• The aim is to develop a multifunctional hydrogel that combines antibacterial properties with tissue regeneration capabilities for treating infected wounds.
• Developed a supramolecular hydrogel using Ure2 amyloid peptides and silver nanoparticles (Ag NPs) through a controlled self-assembly strategy.
• Evaluated the hydrogel's mechanical strength, adhesion properties, and antibacterial activity in laboratory conditions.
• Conducted in vitro and in vivo tests to assess bacterial growth suppression and wound healing acceleration.
• The composite hydrogel showed excellent adhesion and mechanical strength while maintaining sustained antibacterial activity.
• Significant inhibition of bacterial growth was observed with the hydrogel, leading to faster healing of infected wounds.
• Demonstrated potential for clinical application in complex wound repair and tissue regeneration.