The research aims to explore how manipulation therapy affects neuropathic pain through an epigenetic mechanism.
Conducted experiments to evaluate the effects of manipulation therapy on neuropathic pain.
Measured inflammation and RNA m6A methylation changes in the spinal cord.
Utilized the SOCS1/TLR4 pathway as a focal point of investigation.
Manipulation therapy significantly reduced levels of neuropathic pain.
It altered inflammation markers in the spinal cord.
m6A methylation was modified, linking epigenetic changes to pain relief.
Abstract
This study provides evidence that MT effectively ameliorates NP by modulating inflammation and RNA m6A methylation in the spinal cord via the SOCS1/TLR4 pathway.