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March 21, 2026International Journal of Obesity3 citationsOpen Access

Association of body mass index, waist circumference, (abdominal) overweight and obesity with sex- and age-specific cognitive function over time—the Doetinchem Cohort Study

FHFemke te HoonteMRM. Liset RietmanKWKirsten E. J. Wesenhagen

Key Points

  • This research investigates how body mass index and waist circumference relate to cognitive function across different ages and sexes.
  • Analyzed longitudinal data from the Doetinchem Cohort Study.
  • Examined associations between BMI, waist circumference, and cognitive performance.
  • Considered sex-specific and age-related effects.
  • Higher BMI and waist circumference are associated with poorer cognitive function in both sexes.
  • Waist circumference showed a stronger link with cognition than BMI.
  • Only men exhibited significant cognitive decline related to these measurements.

Abstract

In both sexes, higher BMI and WC were consistently associated with worse cognition. WC-based overweight and obesity showed larger effect sizes with cognition than BMI-based overweight and obesity. Only in men, associations with cognitive decline and effect modification by age were observed.

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Cite This Study

Hoonte et al. (2026) studied this question.

synapsesocial.com/papers/69be35166e48c4981c673265https://doi.org/10.1038/s41366-026-02034-1
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