What question did this study set out to answer?

This research investigates how body mass index and waist circumference relate to cognitive function across different ages and sexes.

March 21, 2026International Journal of Obesity3 citationsOpen Access

Association of body mass index, waist circumference, (abdominal) overweight and obesity with sex- and age-specific cognitive function over time—the Doetinchem Cohort Study

FHFemke te HoonteUniversity Medical Center Utrecht MRM. Liset Rietman KWKirsten E. J. WesenhagenNational Institute for Public Health and the Environment

Key Points

This research investigates how body mass index and waist circumference relate to cognitive function across different ages and sexes.
Analyzed longitudinal data from the Doetinchem Cohort Study.
Examined associations between BMI, waist circumference, and cognitive performance.
Considered sex-specific and age-related effects.
Higher BMI and waist circumference are associated with poorer cognitive function in both sexes.
Waist circumference showed a stronger link with cognition than BMI.
Only men exhibited significant cognitive decline related to these measurements.

Abstract

In both sexes, higher BMI and WC were consistently associated with worse cognition. WC-based overweight and obesity showed larger effect sizes with cognition than BMI-based overweight and obesity. Only in men, associations with cognitive decline and effect modification by age were observed.

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