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November 10, 2025Journal of Alzheimer s Disease

Obesity, cardiometabolic health status, and brain health in community-dwelling older adults

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Authors

KAKathryn H. AlphinCSCynthia K. SuerkenMRMarc D. Rudolph

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Implication

Observational study finds obesity linked to better cognition in older adults, indicating possible protective effects against dementia.

Key Points

  • Investigate associations between obesity measures and brain health in community-dwelling older adults.
  • Examined 599 participants with brain MRI and cognitive testing.
  • Used Chi square and one-way ANOVA for comparing characteristics across BMI categories.
  • Applied linear regression models to assess relationships between obesity measures and cognitive outcomes.
  • Higher BMI linked to increased cerebral blood flow in gray and white matter.
  • Obesity measures correlated with better cognition and cognitive composite scores.
  • Effect modification observed by APOE ε4 status for various brain health measures.

Cite This Study

Alphin et al. (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356d3fhttps://doi.org/10.1177/13872877251393500
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract P327: Examination of Cardiometabolic Health Status, Obesity, and Brain Health in Community-Dwelling Older Adults2024
  2. 2Abdominal obesity and white matter microstructure in midlife2017 · 43 citations
  3. 3Abstract DP335: Association of Midlife and Late-life Obesity and Adiposity Measures with Late-life Brain Amyloid Deposition: An Atherosclerosis Risk in Communities Study2026
  4. 4Obesity is associated with reduced cerebral blood flow – modified by physical activity2021 · 84 citations
  5. 5Adiposity and Cognitive Performance in Older Men and Women from the Study of Muscle, Mobility and Aging (SOMMA)2026