Key result
Overweight or high waist-to-hip ratio/waist circumference combined with low/moderate physical activity was associated with up to 3 ml/100g/min lower gray matter cerebral blood flow (p≤0.011).
Why the study?
The study examined the associations of body mass index, waist-to-hip ratio, waist circumference, and physical activity with gray matter cerebral blood flow in older adults.
Does physical activity modify the association between obesity and reduced gray matter cerebral blood flow in older adults?
Population
495 older adults from the Irish Longitudinal Study on Ageing
Comparison
Associations across BMI, WHR, WC, and physical activity levels
Design
Cross-sectional study
Authors
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Does not warrant clinical changes for weight or activity; leaves open causal effects on gray matter perfusion.
Cross-Sectional (n=495)
Does physical activity modify the association between obesity and reduced gray matter cerebral blood flow in older adults?
Effect estimate: up to 3 ml/100g/min lower
p-value: p=≤0.011
High physical activity may mitigate the negative impact of obesity on cerebral blood flow in older adults, potentially offering a cost-effective strategy against cerebral hypoperfusion.
Knight et al. (2021) conducted a cross-sectional in Older adults (n=495). Obesity (BMI, WHR, WC) and physical activity vs. Normal weight / high physical activity was evaluated on Gray matter cerebral blood flow (CBFGM) (up to 3 ml/100g/min lower, p=≤0.011). Overweight or high waist-to-hip ratio/waist circumference combined with low/moderate physical activity was associated with up to 3 ml/100g/min lower gray matter cerebral blood flow (p≤0.011).
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