Why the study?
Low physical activity and obesity are dementia risk factors, but whether the association between physical activity and brain health depends on the degree of obesity remains unclear.
Does greater physical activity improve brain structure volumes in a midlife community cohort?
Does greater physical activity improve brain structure volumes in a midlife community cohort?
Greater physical activity is associated with healthier brain volumes, but this relationship is partially or fully mediated by BMI and other cardiometabolic risk factors.
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Associations of physical activity with brain volumes attenuated by BMI and cardiometabolic factors; leaves open whether activity independently preserves brain structure.
Hood et al. (2025) studied this question.
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