ALS motor phenotypes: a revised ‘OPM’ classification

Key Points

• The research aims to enhance the routine capture of motor phenotypes in ALS for clinical and research applications.
• Developed a revised classification system for ALS motor phenotypes
• Focused on feasibility and practicality for clinical use
• Evaluated applicability in therapeutic trials
• The revised classification system standardizes motor phenotype capture
• It is practical for widespread adoption in clinical settings
• Supports improved outcomes in ALS therapeutic trials