What question did this study set out to answer?

The study aims to evaluate how 19-hydroxybufalin affects gastric cancer cell growth and its potential mechanisms.

March 21, 2026Journal of Proteome Research1 citations

19-Hydroxybufalin Inhibits Gastric Cancer Cell Proliferation by Modulating Metabolic Reprogramming

XLXiao LiangJiangnan University YLYe LiuHenan University XMXiaoting MaXuzhou Medical College

Key Points

The study aims to evaluate how 19-hydroxybufalin affects gastric cancer cell growth and its potential mechanisms.
Investigated the effects of 19-hydroxybufalin on gastric cancer cells
Analyzed the impact on cellular proliferation
Targeted the phospholipase PLPP2 for metabolic changes
19-hydroxybufalin significantly inhibits the proliferation of gastric cancer cells
PLPP2 is identified as a potential therapeutic target
Metabolic reprogramming is altered in response to treatment

Abstract

19-H exerts its antigastric cancer effect by targeting PLPP2 and remodeling the metabolic network. PLPP2 may represent a novel therapeutic target for gastric cancer.

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