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March 21, 2026Oral Diseases1 citationsOpen Access

Clinicopathological and Prognostic Features of Pleomorphic Adenoma, Recurrent Pleomorphic Adenoma, and Carcinoma ex Pleomorphic Adenoma: A 20‐Year Retrospective Analysis

TKTalita de Carvalho KimuraUniversidade Estadual de Campinas (UNICAMP)LLLuccas LavarezeUniversidade Estadual de Campinas (UNICAMP)RLReydson Alcides de Lima‐SouzaUniversidade Estadual de Campinas (UNICAMP)

Key Points

This research aims to compare the clinical and pathological profiles of pleomorphic adenoma, recurrent pleomorphic adenoma, and carcinoma ex pleomorphic adenoma, focusing on survival predictors.
Conducted a 20-year retrospective analysis on clinical and pathological data
Categorized cases into pleomorphic adenoma, recurrent pleomorphic adenoma, and carcinoma ex pleomorphic adenoma
Analyzed histological factors related to survival outcomes
Distinct clinical profiles were observed among pleomorphic adenoma, recurrent pleomorphic adenoma, and carcinoma ex pleomorphic adenoma
In carcinoma ex pleomorphic adenoma, strong correlation between clinical and histological factors and patient survival was found
Identified factors that can effectively guide risk stratification and therapeutic decisions

Abstract

This retrospective study demonstrates distinct clinical and pathological profiles across PA, RPA, and CXPA. In CXPA, clinical and histological factors strongly predict survival and should guide risk stratification, therapeutic decisions, and follow-up strategies.

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