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March 21, 2026Neurology2 citations

Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia

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EPEmma Louise PalatsidesDHDibya HimaliLCLachlan Cribb

Key Points

  • This research aims to explore the association between the AQP4 haplotype, cognitive function, and the risk of developing dementia.
  • Examined the AQP4 gene variations in community-dwelling individuals
  • Analyzed the relationship between AQP4 haplotype and cognitive abilities
  • Measured brain volumes using imaging techniques
  • Assessed dementia risk in participants over time
  • Identified a significant association between the AQP4 haplotype and cognitive performance
  • Found reduced brain volumes linked to specific AQP4 variations
  • Reported increased risk of dementia in individuals with certain AQP4 gene variants

Abstract

The aquaporin-4 (AQP4) water channel plays an integral role in clearing brain waste. However, little is known about whether variations in the AQP4 gene contributes to brain health or dementia risk. We aimed to determine whether a functional AQP4 haplotype was associated with cognition, brain volumes, or incident dementia.

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Cite This Study

Palatsides et al. (2026) studied this question.

synapsesocial.com/papers/69be36bf6e48c4981c675dbfhttps://doi.org/10.1212/wnl.0000000000214773
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