What question did this study set out to answer?

This research aims to explore the association between the AQP4 haplotype, cognitive function, and the risk of developing dementia.

March 21, 2026

Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia

Key Points

This research aims to explore the association between the AQP4 haplotype, cognitive function, and the risk of developing dementia.
Examined the AQP4 gene variations in community-dwelling individuals
Analyzed the relationship between AQP4 haplotype and cognitive abilities
Measured brain volumes using imaging techniques
Assessed dementia risk in participants over time
Identified a significant association between the AQP4 haplotype and cognitive performance
Found reduced brain volumes linked to specific AQP4 variations
Reported increased risk of dementia in individuals with certain AQP4 gene variants

Abstract

The aquaporin-4 (AQP4) water channel plays an integral role in clearing brain waste. However, little is known about whether variations in the AQP4 gene contributes to brain health or dementia risk. We aimed to determine whether a functional AQP4 haplotype was associated with cognition, brain volumes, or incident dementia.

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