Examines the link between AQP4 haplotype, cognition, and dementia risk in individuals without dementia, suggesting potential health implications.
The aquaporin-4 (AQP4) water channel plays an integral role in clearing brain waste. However, little is known about whether variations in the AQP4 gene contributes to brain health or dementia risk. We aimed to determine whether a functional AQP4 haplotype was associated with cognition, brain volumes, or incident dementia.
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Palatsides et al. (2026) studied this question.
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