Prediction-guided clustering for sepsis phenotyping: a retrospective cohort analysis

Key Points

• This research aims to develop a framework for identifying clinically relevant sub-phenotypes in sepsis patients.
• Conducted a retrospective cohort analysis of sepsis patients.
• Implemented a prediction-guided clustering framework.
• Assessed clinical interpretability of identified sub-phenotypes.
• Identified clinically meaningful sub-phenotypes among sepsis patients.
• Proposed an effective strategy for personalized medicine.
• Demonstrated potential for improved patient outcomes through tailored treatment approaches.