Sequential feeding alters hepatic circadian rhythm gene expression and lipid levels in septic mice

Key Points

• This research investigates how sequential feeding influences liver gene expression and lipid levels in septic mice.
• Administered sequential and continuous feeding to septic mice.
• Measured serum cholesterol and triglyceride levels.
• Assessed expression of hepatic circadian rhythm-related genes at specific times.
• Sequential feeding preserved differential expression of certain liver genes at 08:00 and 20:00.
• Continuous feeding decreased the differential gene expression.
• Severe liver fat buildup was observed with continuous feeding.