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September 16, 2018New England Journal of MedicineOpen Access

Low-dose aspirin resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo.

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Why the study?

Does low-dose aspirin prevent cardiovascular disease in healthy older adults?

Population

Healthy older adults

Comparison

Low-dose aspirin vs Placebo

Design

RCT

Authors

JMJohn J. McNeilRWRory WolfeRWRobyn L. Woods

Discussion

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Overview

Low-dose aspirin should not be used for primary CVD prevention in healthy older adults; challenges prior guidelines and reinforces net harm in this population.

Structured PICO

Does low-dose aspirin prevent cardiovascular disease in healthy older adults?

P
Population
Healthy older adults
I
Intervention
Low-dose aspirin
C
Comparator
Placebo
O
Outcome
Cardiovascular disease and major hemorrhagehard clinical

Low-dose aspirin is not effective for primary cardiovascular prevention in healthy older adults and significantly increases the risk of major hemorrhage.

Cite This Study

McNeil et al. (2018) studied this question.

synapsesocial.com/papers/69c0251446f5f4fe05a0cffehttps://doi.org/10.1056/nejmoa1805819
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