September 16, 2018New England Journal of Medicine1,144 citationsOpen Access
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
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Structured PICO
Does low-dose aspirin prevent cardiovascular disease in healthy older adults?
P
Population
Healthy older adults
I
Intervention
Low-dose aspirin
C
Comparator
Placebo
O
Outcome
Cardiovascular disease and major hemorrhagehard clinical
Low-dose aspirin is not effective for primary cardiovascular prevention in healthy older adults and significantly increases the risk of major hemorrhage.
Abstract
The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).
Cite This Study
McNeil et al. (2018) studied this question.