Why the study?
Does daily aspirin for primary prevention increase risk for major GI bleeding in healthy older adults?
Does daily aspirin for primary prevention increase risk for major GI bleeding in healthy older adults?
In healthy older adults, daily aspirin for primary prevention increases the risk of major gastrointestinal bleeding.
Answers are grounded in this paper and cite their sources.
Aspirin confers elevated major GI bleeding risk in older adults; extends RCT-derived risk factor data for primary prevention decisions.
Source Citation Mahady SE, Margolis KL, Chan A, et al. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2020. [Epub ahead of print.] 32747412
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Calvin H. Hirsch (2021) studied this question.
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