Key result
Aspirin increases major GI bleeding risk ~61% vs. placebo in older adults.
Why the study?
There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin.
RCT (n=19,114)
Double-blind
1:1 ratio, computer-generated
Yes
Hazard Ratio: 1.61 (95% CI 1.26–2.08)
p-value: p=0.002
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Aspirin raises major GI bleeding risk in adults ≥70 for primary prevention; extends ASPREE RCT data with age- and comorbidity-stratified absolute risks.
Mahady et al. (2020) conducted an RCT in Primary prevention of cardiovascular disease (n=19,114). Aspirin vs. Placebo was evaluated on Major GI bleeding that resulted in transfusion, hospitalisation, surgery or death (HR 1.61, 95% CI 1.26 to 2.08, p=0.002). Aspirin increased the risk of overall major gastrointestinal bleeding by 61% (HR 1.61) compared to placebo in community-dwelling older adults.
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