Nasal RNA-scaffold-protein vaccine protects mice from human H5N1 clade 2.3.4.4b virus lethal infection and safeguards against vaccine-unmatched viruses | Synapse
Nasal RNA-scaffold-protein vaccine protects mice from human H5N1 clade 2.3.4.4b virus lethal infection and safeguards against vaccine-unmatched viruses
The aim is to evaluate the effectiveness of a nasal RNA-scaffold-protein vaccine against the H5N1 virus.
Experiment conducted on mice to assess the vaccine's protective effects.
Mice were exposed to the human H5N1 clade 2.3.4.4b virus post-vaccination.
Immune response and survival rates were monitored.
The vaccine significantly protected mice from lethal H5N1 virus infection.
It also provided protection against other unmatched viruses.
Mice vaccinated showed a robust immune response.
Abstract
This study is supported by the Health@InnoHK initiative of the Innovation and Technology Commission of the Hong Kong Special Administrative Region Government.