Increase of post–SARS‐CoV‐2 rashes mimicking penicillin allergy in children with Group A beta‐hemolytic Streptococcus infection: An emerging and challenging issue | Synapse
March 25, 2026
Increase of post–SARS‐CoV‐2 rashes mimicking penicillin allergy in children with Group A beta‐hemolytic Streptococcus infection: An emerging and challenging issue
Key Points
This research examines the association between Group A beta-hemolytic Streptococcus infections and rashes that resemble penicillin allergies.
Observational analysis of children with GABHS infection
Assessment of skin rashes observed post-SARS-CoV-2 infection
Exclusion of penicillin allergy through negative delayed-type penicillin tests (DPTs)
A significant number of children exhibited rashes after SARS-CoV-2 infection
These rashes were commonly mistaken for penicillin allergies
Negative DPTs confirmed that these rashes were not due to penicillin hypersensitivity
Abstract
GABHS may be associated with a rash that mimics delayed penicillin allergy, which is excluded by negative DPTs.