Manganese-Activatable Nano-Hydroxyapatite Nanoparticles as Self-Adjuvanting STING Activators for Synergistic Melanoma Therapy

Key Points

• The research aims to explore the potential of manganese-activatable nanoparticles as immunotherapy agents for melanoma treatment.
• Developed manganese-activatable nano-hydroxyapatite nanoparticles
• Evaluated their effect on the tumor microenvironment
• Assessed synergistic effects with other treatments
• Enhanced immune response against melanoma
• Significantly reduced tumor growth
• Improved therapeutic outcomes compared to conventional therapies