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March 26, 2026AJP Lung Cellular and Molecular PhysiologyOpen Access

Modulation of Alveolar Macrophages by Sex as a Biological Variable

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Authors

SSShilpa SontiCLConnor LeekKLKrithika Lingappan

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Overview

Examines the effects of biological sex on the function of alveolar macrophages in neonatal lungs, suggesting implications for personalized treatments.

Key Points

  • The research aims to understand how biological sex influences the metabolic resilience of alveolar macrophages in response to hyperoxia.
  • Characterized bioenergetic profiles of male and female murine alveolar macrophage cell lines.
  • Quantified oxygen consumption and extracellular acidification rates using Seahorse extracellular flux analysis.
  • Conducted experiment with exposure to hyperoxia over 48 hours.
  • Female alveolar macrophages exhibited higher basal and maximal respiration than male counterparts.
  • Upon hyperoxia exposure, female macrophages had reduced maximal oxygen consumption rate and spare respiratory capacity, unlike males who showed minimal change.
  • Neonatal macrophages from both sexes experienced mitochondrial function suppression under hyperoxia, with a more significant decline in males.

Cite This Study

Sonti et al. (2026) studied this question.

synapsesocial.com/papers/69c4cc75fdc3bde448917c89https://doi.org/10.1152/ajplung.00410.2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A106-02 Sex as a Biological Variable and Immunometabolism: Focus on Alveolar Macrophages2026
  2. 2Role of sex as a biological variable in neonatal alveolar macrophages2024 · 11 citations
  3. 3Influence of Biological Sex in Macrophage Immunometabolic Reprogramming2026
  4. 4B17-02 Sex as a Biological Variable in Neonatal Hyperoxic Lung Injury: The Role of Sex Chromosome Dosage2026
  5. 5Effect of Sex on Sympatho-inhibitors and Non-inhibitor Phenotypes during Acute Hyperoxia2024 · 1 citations