What question did this study set out to answer?

The aim is to assess how different doses of propofol influence serum triglyceride levels in critically ill patients.

March 26, 2026Critical Care Medicine0 citations

1451: Dose-Response Effect of Propofol Upon Serum Triglyceride Concentrations in Critically Ill Patients

JWJonathon Walker ELEmma Lemke JFJulie E. FarrarUniversity of Tennessee Health Science Center

Key Points

The aim is to assess how different doses of propofol influence serum triglyceride levels in critically ill patients.
Retrospective evaluation of adult patients receiving continuous intravenous propofol infusion for at least 24 hours.
Determination of serum triglyceride levels and documentation of fluid intake and output.
Analysis of dose-response relationship using linear and nonlinear correlation methods.
A total of 195 triglyceride determinations were made in 100 patients, with 25 developing hypertriglyceridemia.
The hypertriglyceridemic group showed a significant concave non-linear relationship between lipid dose and triglyceride levels (r=0.731, p=0.001).
In contrast, the non-hypertriglyceridemic group's response was flatter and linear with poorer correlation (r=0.263, p=0.002).

Abstract

Introduction: This study aimed to evaluate the dose-response effect of continuous intravenous lipid-emulsion containing propofol infusion upon serum triglyceride concentrations (TG) in critically ill trauma patients. Methods: Adult patients, >17 yrs old, who received a continuous intravenous propofol infusion for at least 24 hours and had a TG determination, and had accurate fluid intake and output documentation were retrospectively included for evaluation. The amount of lipid emulsion from propofol given 24 hours prior to TG determination was used to evaluate the dose-TG response relationship. Patients were classified as hypertriglyceridemic (hyperTG) if TG was > 400 mg/dl. The dose-TG response relationship was examined for the hyperTG and non-hyperTG groups. Linear and nonlinear correlative relationships were interpolated for the best fit using curve-fitting software. Continuous data are given as median 25th,75th percentile. A p value 1000 mg/dl. Lipid intake from propofol was greater in those with hyperTG (0.22 0.15, 0.45 g/kg/d vs 0.13 0.1, 0.25 g/kg/d, p=0.002). The best fit, defined by the highest correlation (r), was non-linear and linear for the hyperTG and non-hyperTG groups, respectively. The hyperTG group (n=57 TG determinations) exhibited a significant concave non-linear relationship (TG=29 + 292*elipid dose(g/kg/d); r=0.731, p=0.001) between lipid dose and TG as the lipid dose increased. The non-hyperTG group (n=138 TG determinations) had a flattened dose-TG response with a poor linear relationship (TG=160 + 61*lipid dose(g/kg/d); r=0.263, p=0.002). Conclusions: The hyperTG group exhibited a non-linear concave dose-TG response with evidence of triglyceride accumulation whereas the non-hyperTG group’s dose-TG response was flattened with increases in propofol dosage. Due to unpredictability in dose-TG response, frequent TG monitoring is warranted for patients who receive prolonged or high doses of propofol.

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