To examine the relationship between HIV infection and hyperuricemia in men and women, focusing on influencing factors.
Analyzed the prevalence of hyperuricemia in HIV-positive men and women.
Assessed body mass index (BMI) and albumin-to-globulin ratio (AGR) levels.
Compared metabolic profiles between genders.
Investigated mediation effects of BMI and AGR on hyperuricemia risk.
Men with HIV showed a significantly lower risk of hyperuricemia compared to women.
Lower BMI and AGR levels were found in HIV-positive men.
Metabolic profiles differ between male and female individuals with HIV, influencing hyperuricemia risk.
Abstract
HIV infection was associated with a lower risk of hyperuricemia in men but not women, partially mediated by lower BMI and AGR, suggesting distinct metabolic and inflammatory profiles in male PWH.