Multiple consecutive daily therapeutic plasma exchange using exclusively albumin replacement fluid in low bleeding risk patients is associated with only rare and mild bleeds

Key Points

• To evaluate the safety of multiple daily therapeutic plasma exchanges using albumin in low bleeding risk patients.
• Conducted therapeutic plasma exchange (TPE) up to five consecutive days
• Used exclusively albumin as the replacement fluid
• Did not perform empiric coagulation or fibrinogen testing
• Patients experienced only rare and mild bleeding events
• No severe bleeding was reported
• The approach demonstrates a favorable safety profile