Barbatic acid (BA), a phenolic compound isolated from Pyrrosia petiolosa (Christ) Ching, was investigated for its diuretic effects and underlying mechanisms following oral administration in rats using UPLC-MS/MS-based metabolomics and pharmacokinetics. In a water-loaded rat model, BA (28 and 56 mg/kg) significantly increased 6 h urine output (1.5-fold vs. model, p 0.99). These findings provide the first integrated evidence supporting BA as a potential novel diuretic agent with a mechanism involving amino acid metabolism regulation.
Liang et al. (Wed,) studied this question.
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