TDP-43 is coming to the cottage: A new tool to study neurodegenerative diseases

Key Points

• The central aim is to develop a system that models the dual pathologies of TDP-43 in neurodegenerative diseases.
• Developed a new system to model TDP-43 features.
• Captured loss of TDP-43 from the nucleus and formation of clumps in the cytoplasm.
• Successfully modeled TDP-43 loss and aggregation.
• Demonstrated that the system effectively replicates dual pathologies of TDP-43.