Wcn26-4373 Prolonged Renal Hypoperfusion After Ischemia-Reperfusion Injury in Conscious, Chronically Instrumented Rats

Key Points

• To examine the effects of prolonged renal hypoperfusion resulting from ischemia-reperfusion injury in rats.
• Used a chronic rat model with instrumentation to monitor renal blood flow.
• Induced ischemia-reperfusion injury to evaluate its impact on renal perfusion.
• Measured renal parameters over a specified recovery period.
• Demonstrated significant prolonged renal hypoperfusion post-injury.
• Observed impaired kidney function correlating with the duration of hypoperfusion.
• Identified critical time points for potential therapeutic intervention.