What question did this study set out to answer?

The study aims to investigate the association between circulating osteoprotegerin levels and peripheral arterial stiffness in chronic kidney disease.

March 28, 2026Kidney International Reports0 citationsOpen Access

Wcn26-4702 Use of Laxatives by CKD Stage and Serum Magnesium Measurement Status During Use of Magnesium-Containing Laxatives

ASAsuka SakakimotoJapanese Red Cross Society Wakayama Medical Center KTKazuo TAKIJapanese Red Cross Society Wakayama Medical Center KTKazufumi TanabeJapanese Red Cross Society Wakayama Medical Center

Key Points

The study aims to investigate the association between circulating osteoprotegerin levels and peripheral arterial stiffness in chronic kidney disease.
Conducted cross-sectional analysis with 200 adults diagnosed with chronic kidney disease.
Measured brachial-ankle pulse wave velocity (baPWV) and serum osteoprotegerin levels.
Classified participants into peripheral arterial stiffness (PAS) and control groups based on baPWV measurements.
43% of CKD patients exhibited peripheral arterial stiffness.
Serum osteoprotegerin levels were significantly higher in the PAS group (P < 0.001).
Serum osteoprotegerin remained independently associated with PAS even in adjusted models (OR: 1.008, P = 0.010).
OPG demonstrated fair diagnostic performance for identifying PAS (AUC: 0.721, P < 0.0001).

Abstract

Introduction: Peripheral arterial stiffness (PAS) is prevalent in chronic kidney disease (CKD) and contributes to cardiovascular risk.We investigated whether circulating osteoprotegerin (OPG), a cytokine linked to vascular calcification, is associated with PAS assessed by brachial-ankle pulse wave velocity (baPWV) in CKD.Methods: In a cross-sectional cohort of 200 adults with CKD, left/right baPWV, clinical characteristics, and serum OPG were measured.The serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit.Patients with left or right baPWV >18.0 m/s were classified in the PAS group, whereas those with baPWV # 18.0 m/s were assigned to the control group.Results: Out of 200 non-dialysis CKD patients, 86 (43%) were in PAS groups.Compared with the control group, the rates of diabetes mellitus (DM, P = 0.023), hypertension (P = 0.010), old age (P < 0.001), systolic blood pressures (P < 0.001), spot urine protein-to-creatinine ratio (UPCR, P = 0.004), as well as the serum levels of OPG (P < 0.001), were higher, while estimated glomerular filtration rate (eGFR, P = 0.003) were lower in the PAS group.In fully adjusted models, OPG (per 1 pg/ mL) remained independently associated with PAS (odds ratio OR: 1.008, 95% confidence interval CI: 1.002-1.015,P = 0.010), along with older age (OR: 1.069, 95% CI: 1.027-1.112,P = 0.001) and DM (OR: 2.745, 95% CI: 1.282-5.876,P = 0.009).Additionally, a positive association was found between the serum logarithmically transformed OPG (log-OPG) levels and either the left or right baPWV (all P < 0.001, respectively) in non-dialysis CKD patients according to the Spearman's rank correlation coefficient test.OPG discriminated PAS with an area under the curve of 0.721 (95% CI: 0.651-0.792,P < 0.0001).Conclusion: In CKD, higher circulating OPG is independently associated with the presence of PAS and correlates with greater baPWV.OPG shows fair diagnostic performance for identifying PAS and may serve as a vascular risk marker in CKD.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

问 AI

Bookmark

View Full Paper

Cite This Study

Sakakimoto et al. (Wed,) studied this question.

synapsesocial.com/papers/69c770c08bbfbc51511e0c11 https://doi.org/https://doi.org/10.1016/j.ekir.2026.104228

问 AI

Bookmark

View Full Paper