Nonalcoholic fatty liver disease was not independently associated with an increased risk of new-onset atrial fibrillation (HR 0.93) after adjusting for shared cardiometabolic risk factors.
Cohort (n=92,581)
Yes
Does nonalcoholic fatty liver disease (NAFLD) increase the risk of new-onset atrial fibrillation in adults?
NAFLD is not an independent risk factor for atrial fibrillation; the previously observed association is likely driven by shared cardiometabolic risk factors such as obesity.
Effect estimate: HR 0.93 (95% CI 0.84-1.02)
Absolute Event Rate: 5.27% vs 2.57%
p-value: p=0.12
S: : In this large cohort study from the UK Biobank, NAFLD was not an independent risk factor for AF. This implies that the increased incidence of AF observed in participants with NAFLD may be more closely related to cardiometabolic risk factors contributing to the development of NAFLD rather than the condition itself.
Zhai et al. (Wed,) conducted a cohort in Nonalcoholic fatty liver disease (NAFLD) (n=92,581). Nonalcoholic fatty liver disease (NAFLD) vs. Non-NAFLD was evaluated on New-onset atrial fibrillation (HR 0.93, 95% CI 0.84-1.02, p=0.12). Nonalcoholic fatty liver disease was not independently associated with an increased risk of new-onset atrial fibrillation (HR 0.93) after adjusting for shared cardiometabolic risk factors.