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Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes | Synapse

March 28, 2026Diabetes Obesity and Metabolism0 citationsOpen Access

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Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes

GLGuk Jin Lee SJSang‐Hyuk Jung JLJonghyun Lee

Key Points

This research aims to evaluate the role of polygenic risk scores in predicting prostate cancer risk, especially in men with type 2 diabetes.
Assessed prostate cancer risk using polygenic risk scores among men with and without type 2 diabetes.
Measured IGF-1 levels to explore potential mediating effects in type 2 diabetes patients.
Polygenic risk scores effectively stratified prostate cancer risk among both groups.
Men with type 2 diabetes exhibited lower prostate cancer risk, potentially linked to reduced IGF-1 levels.

Abstract

PrCa PRS effectively stratifies risk among men with and without T2DM, highlighting the independent contribution of genetic susceptibility. Lower IGF-1 levels in T2DM patients may partly mediate the reduced PrCa risk, suggesting a possible biological mechanism underlying these observations.

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Cite This Study

Lee et al. (Thu,) studied this question.

synapsesocial.com/papers/69c770f78bbfbc51511e0d8c https://doi.org/https://doi.org/10.1111/dom.70690