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June 23, 2025SHILAP Revista de lepidopterologíaOpen Access

Cardiac-secreted EVs abundant with miRNA-21 communicate with the brain and promote microglial activation, leading to neuroinflammation following myocardial injury.

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Why the study?

Cognitive impairment is common in heart failure and may link to neuroinflammation, but the heart-brain axis remains incompletely understood.

Does myocardial injury induce neuroinflammation through extracellular vesicle-mediated heart-brain crosstalk?

Population

Rodent myocardial injury model and in vitro cell models

Design

Preclinical animal and in vitro experimental study

Authors

QLQingxuan LiRHRamzi H HamdallaNDNeha Dhyani

Discussion

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Member takes

Overview

Raises possibility of post-MI heart-brain crosstalk; hypothesis-generating in animals and leaves open human relevance.

Structured PICO

Does myocardial injury induce neuroinflammation through extracellular vesicle-mediated heart-brain crosstalk?

P
Population
Rodent myocardial injury model and in vitro cell cultures (microglia, cardiac cells)
I
Intervention
Myocardial injury and exposure to cardiac-derived extracellular vesicles (EVs) enriched with miRNA-21
O
Outcome
Extracellular vesicle (EV)-mediated heart-brain crosstalk, glial uptake of cardiac EVs, and brain inflammation/microglial activationsurrogate

This study identifies a novel heart-brain axis mechanism where cardiac-derived extracellular vesicles enriched with miRNA-21 drive neuroinflammation and microglial activation after myocardial injury.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69cbea2310f9bc3d9afcf01bhttps://doi.org/10.1016/j.jacbts.2025.05.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart–Brain Axis in Viral Myocarditis: Shared Cytokine Pathways, Blood–Brain Barrier Crosstalk, and Neuroinflammatory Consequences2026 · 5 citations
  2. 2The Neurocardiac Axis in Myocardial Infarction: Emerging Role of Brain-Heart Inflammatory Signaling2026
  3. 3Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice2026
  4. 4Neurogenic Stress Cardiomyopathy: What Do We Need to Know2018 · 47 citations
  5. 5Differential Effects of Ischemia and Inflammation on Plasma-Derived Extracellular Vesicle Characteristics and Function in a Mouse Model2026