miR-138-5p Promotes HF in Rats by Reducing Histone Methylation in the Myd88 Promoter Region through Inhibition of EZH2.

Key Points

• The central aim is to investigate how miR-138-5p influences heart failure by modulating histone methylation in the Myd88 promoter.
• Experimental design involved in vitro and in vivo rat models.
• Assessment of EZH2 expression levels and H3K27me3 methylation.
• Measurement of Myd88 expression and cardiomyocyte apoptosis rates.
• miR-138-5p expression was found to inhibit EZH2 levels.
• Reduced H3K27me3 methylation was correlated with increased Myd88 expression.
• Enhanced Myd88 expression was linked to higher rates of cardiomyocyte apoptosis, suggesting a role in heart failure.