Cystatin B Attenuates Cerebral Ischemia Reperfusion Injury by Inhibiting the JAK2 / STAT3 Signaling Pathway

Key Points

• The research aims to identify the role of cystatin B as a negative regulator in cerebral ischemia reperfusion injury.
• Identified cystatin B's effects on cerebral ischemia reperfusion injury (CIRI) in vitro.
• Examined its role in inhibiting apoptosis and reducing inflammatory responses.
• Analyzed the involvement of the JAK2/STAT3 signaling pathway.
• Cystatin B significantly reduced apoptosis in CIRI models.
• Inhibition of the JAK2/STAT3 pathway was observed with cystatin B treatment.
• Cystatin B administration correlated with decreased inflammatory responses.