Phytochemical profiling of Euphorbia tirucalli Linn. latex and evaluation of its in vitro antibacterial activity against resistant Klebsiella pneumoniae : an integrative network pharmacology and molecular dynamics simulation study

Key Points

• The main aim is to evaluate the antibacterial properties of Euphorbia tirucalli latex against resistant Klebsiella pneumoniae and identify potential target interactions.
• Conducted phytochemical profiling of Euphorbia tirucalli latex metabolites.
• Assessed antibacterial activity through in vitro experiments against Klebsiella pneumoniae.
• Utilized network pharmacology and molecular dynamics simulations to support target interaction findings.
• Euphorbia tirucalli latex metabolites demonstrated modest antibacterial activity against the resistant strain of Klebsiella pneumoniae.
• Network pharmacology suggests potential therapeutic targets related to lactate metabolism and membrane integrity.