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March 21, 2017European Heart Journal412 citationsOpen Access

Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study

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TCThomas CuissetPDPierre DeharoJQJacques Quilici

Structured PICO

Does a switched DAPT strategy prevent bleeding complications without increasing ischaemic events in patients following acute coronary syndrome?

P
Population
Patients following acute coronary syndrome (ACS)
I
Intervention
Switched dual antiplatelet therapy (DAPT) strategy
C
Comparator
Unchanged dual antiplatelet therapy (DAPT) strategy
O
Outcome
Bleeding complications and ischaemic eventssafety

Switching DAPT after ACS reduces bleeding complications without increasing the risk of ischemic events compared to an unchanged DAPT strategy.

Abstract

A switched DAPT is superior to an unchanged DAPT strategy to prevent bleeding complications without increase in ischaemic events following ACS.

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Cite This Study

Cuisset et al. (2017) studied this question.

synapsesocial.com/papers/69cec2f8e84115fc29c51ecchttps://doi.org/10.1093/eurheartj/ehx175
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