Unraveling the mechanism and probing the origins of stereocontrol in cobalt-catalyzed carboamination reaction

Key Points

• The research aims to explore the reaction mechanism involved in cobalt-catalyzed carboamination and its stereocontrol origins.
• Conducted density functional theory (DFT) calculations
• Analyzed the energy profile of the reaction
• Investigated the reaction of phenoxyacetamide with butyl acrylate
• Identified key energy barriers along the reaction pathway
• Confirmed the viability of the proposed reaction mechanism
• Discovered insights into the stereocontrol factors influencing the outcome