What question did this study set out to answer?

To assess the risk of invasive cancer development in patients with lobular carcinoma in situ (LCIS) and the effects of tamoxifen.

April 3, 2026Journal of Breast Cancer0 citationsOpen Access

Clinical Outcomes of Lobular Carcinoma In Situ : Risk of Invasive Cancer Development

DWDoyoun WoenSamsung Medical Center KKKi Jo KimSamsung Medical Center SLSu Min LeeSamsung Medical Center

Key Points

To assess the risk of invasive cancer development in patients with lobular carcinoma in situ (LCIS) and the effects of tamoxifen.
Evaluation of postoperative tamoxifen effects on patients with pure LCIS.
Comparison of risk between pleomorphic and classic LCIS types.
Analysis of histologic subtypes to guide treatment strategies.
Tamoxifen did not significantly reduce invasive cancer development in patients with pure LCIS.
Pleomorphic LCIS showed a potentially higher risk for invasive cancer compared to classic LCIS.
Recommendations suggest tailored follow-up based on histologic subtype.

Abstract

Postoperative tamoxifen did not significantly lower invasive cancer development in patients with pure LCIS. Pleomorphic LCIS may carry a higher risk than classic LCIS. These findings require tailored follow-up and treatment strategies based on the histologic subtype of LCIS.

问 AI

Bookmark

View Full Paper

Cite This Study

Woen et al. (Thu,) studied this question.

synapsesocial.com/papers/69cf5d605a333a821460b136 https://doi.org/https://doi.org/10.4048/jbc.2025.0272

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

问 AI

Bookmark

View Full Paper