Factors associated with low bone mineral density at diagnosis in pediatric Crohn’s disease: a large retrospective cohort study

Crohn’s disease can adversely affect bone mineral density and low bone mineral density is a concern in pediatric Crohn’s disease. We evaluated factors associated with below-average bone mineral density (z-score ≤ − 1.0) at Crohn’s disease diagnosis. We retrospectively analyzed patients − 1.0, children with z–score ≤ − 1.0 were more often female, had lower hematocrit and weight/height/body mass index z-scores, higher Pediatric Crohn’s Disease Activity Index at diagnosis, and more frequent growth delay (all P < 0.05). Lower weight z-score (OR 0.465, P < 0.001) and growth delay (OR 1.846, P 0.011) were independently associated with below-average bone mineral density. Lower weight z-score and growth delay are independently linked to below-average bone mineral density at Crohn’s disease diagnosis. These findings highlight the importance of evaluating bone mineral density at diagnosis and closely monitoring patients with these risk factors.