Potassium Hydrogen Sulfate Promoted One-pot Synthesis of Bis(indolyl)alkane Esters from α-Keto Carboxylic Acids: In Silico and In Vitro Anticancer Studies

Key Points

• To develop a sustainable and efficient method for synthesizing bis(indolyl)alkane esters and evaluate their anticancer properties.
• Utilized potassium hydrogen sulfate for one-pot synthesis
• Conducted in silico studies to assess bioactivity
• Performed in vitro tests to evaluate anticancer effectiveness
• Successfully synthesized bis(indolyl)alkane esters using a novel method
• Demonstrated significant anticancer activity in vitro
• In silico analysis predicted favorable bioactivity outcomes