What question did this study set out to answer?

To evaluate the impact of adding radiotherapy to first-line chemotherapy on survival in patients with locally advanced pancreatic cancer.

April 3, 2026Cancer Reports0 citationsOpen Access

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Effect of First‐Line Chemotherapy Alone Versus First‐Line Chemotherapy Plus Radiotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer in the IMRT Era: A Retrospective Cohort Study

ZLZihao LiuShandong First Medical University YTYi TianHuazhong Agricultural University JMJi MaShandong Provincial QianFoShan Hospital

Key Points

To evaluate the impact of adding radiotherapy to first-line chemotherapy on survival in patients with locally advanced pancreatic cancer.
Conducted a retrospective cohort study
Compared outcomes of first-line chemotherapy alone versus chemotherapy plus IMRT
Analyzed disease control rate, progression-free survival, and overall survival using statistical tests
Combination therapy improved disease control rate (DCR) significantly (p = 0.038)
No significant difference in progression-free survival (PFS) between groups (p = 0.465)
Overall survival (OS) also showed no significant difference (p = 0.156)

Abstract

The combination of first-line chemotherapy and IMRT improves the DCR rate (p = 0.038) and was well tolerated. However, first-line chemotherapy plus IMRT had no significant difference in PFS (p = 0.465) and OS (p = 0.156) compared with chemotherapy alone.

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Effect of First‐Line Chemotherapy Alone Versus First‐Line Chemotherapy Plus Radiotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer in the IMRT Era: A Retrospective Cohort Study

Key Points

Abstract

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