Does adjunctive Vagus Nerve Stimulation improve response, remission, and suicidality in patients with treatment-resistant depression compared to treatment as usual?
In a 5-year observational registry, adjunctive vagus nerve stimulation provided enhanced antidepressant effects compared to treatment as usual for treatment-resistant depression.
This registry represents the longest and largest naturalistic study of efficacy outcomes in treatment-resistant depression, and it provides additional evidence that adjunctive VNS has enhanced antidepressant effects compared with treatment as usual in this severely ill patient population.
Aaronson et al. (2017) studied this question.