Why the study?
Does adjunctive Vagus Nerve Stimulation improve response, remission, and suicidality in patients with treatment-resistant depression compared to treatment as usual?
Does adjunctive Vagus Nerve Stimulation improve response, remission, and suicidality in patients with treatment-resistant depression compared to treatment as usual?
In a 5-year observational registry, adjunctive vagus nerve stimulation provided enhanced antidepressant effects compared to treatment as usual for treatment-resistant depression.
May support adjunctive VNS in treatment-resistant depression; leaves open need for randomized confirmation.
This registry represents the longest and largest naturalistic study of efficacy outcomes in treatment-resistant depression, and it provides additional evidence that adjunctive VNS has enhanced antidepressant effects compared with treatment as usual in this severely ill patient population.
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Aaronson et al. (2017) studied this question.
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