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The study aims to evaluate the effects of nivolumab and AVD on gonadal function and fertility in patients with Hodgkin lymphoma.

April 4, 2026Blood1 citations

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Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial

ARA. S. RobertzDüsseldorf University Hospital IBIna BühnenDüsseldorf University Hospital JMJulia MeissnerHeidelberg University

Key Points

The study aims to evaluate the effects of nivolumab and AVD on gonadal function and fertility in patients with Hodgkin lymphoma.
Analyzed data from 82 patients with classic Hodgkin lymphoma.
Assessed hormone levels after treatment with 4×N-AVD.
Monitored effects over a period of up to 24 months.
Stable gonadal hormone levels were observed in patients.
Findings indicate preserved gonadal function after treatment.
Fertility remains intact for up to 24 months post-treatment.

Abstract

In 82 patients with classic Hodgkin lymphoma, stable gonadal hormone levels were observed up to 24 months after nivolumab and AVD (N-AVD) first-line treatment in the NIVAHL trial. These findings suggest preserved gonadal function and fertility following 4×N-AVD. NCT03004833

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Gonadal Function and Fertility after Hodgkin Lymphoma Treatment with Nivolumab-AVD in the Phase II GHSG NIVAHL Trial

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Abstract

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