What question did this study set out to answer?

To investigate the association between ultra-processed food consumption and malnutrition and clinical weakness in hemodialysis patients.

April 5, 2026BMC Nephrology0 citationsOpen Access

Ultra-processed food consumption and the prevalence of malnutrition and clinical weakness among hemodialysis patients: a single-center cross-sectional study

RARamazan Mert AtanBandırma Onyedi Eylül University HYHacı Ömer YılmazAcademy of Nutrition and Dietetics

Key Points

To investigate the association between ultra-processed food consumption and malnutrition and clinical weakness in hemodialysis patients.
Cross-sectional study design involving 90 hemodialysis patients.
Evaluated UPF intake using a validated food frequency questionnaire.
Categorized patients into lower and higher UPF consumption groups.
Assessed malnutrition and clinical weakness using NRI and HGS Index.
Performed binary and multivariate logistic regression analyses.
Higher UPF consumption was linked to a 3.70-fold increase in the odds of clinical weakness in higher consumption group.
No significant difference in malnutrition status (NRI values) between the two groups.
HGS Index significantly higher in lower UPF group (89.6 vs 77.7).
No statistical correlation found between UPF intake and malnutrition odds in any model.

Abstract

The consumption of ultra-processed foods (UPFs) is increasing worldwide. However, there is limited information about the relationship between UPFs and kidney health. The study objective was to investigate the relationship between UPF consumption and the odds of malnutrition and clinical weakness in hemodialysis (HD) patients. This is a cross-sectional study evaluating 90 patients. Sociodemographic, anthropometric, and laboratory data were collected. UPF consumption was evaluated by a validated food frequency questionnaire according to the NOVA classification system and patients divided into two groups as lower (M1) and higher (M2) based on the median of UPF consumption. Malnutrition and clinical weakness status of the patients were assessed using Nutritional Risk Index (NRI) and Hand Grip Strength (HGS) Index. Binary and multivariate logistic regression analyses (enter methods) were used to analyze UPFs associated with the odds of clinical weakness and malnutrition. The significance level was set at p < 0.05. The median UPF consumption of patients was 105.5 g. The M1 group had significantly higher pre-postdialysis creatinine, total iron binding capacity (TIBC), total cholesterol and lower pre-postdialysis potassium than the M2 group. Although there was no statistically significant difference in NRI values between the two groups, the HGS index was statistically higher in the M1 group than the M2 group (89.6 ± 24.1, 77.7 ± 23.9, respectively). No significant relationship was found between UPF consumption and the odds of malnutrition in both unadjusted and adjusted models. According to the crude Model, the odds of clinical weakness was 3.70-fold higher in the M2 group (Model 1, 95%CI: 1.41–9.70, p = 0.008). This relationship was also significant in the adjusted models (Model 2, 95%CI: 1.30;11.77, p = 0.015 and Model 3, 95%CI: 1.28;12.08, p = 0.017). The increased UPF consumption was significantly associated with a higher likelihood for clinical weakness, but not malnutrition in HD patients. Not applicable.

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