The aim is to examine how TNFSF12 influences thyroid cancer progression through comprehensive analyses.
Utilized single-cell RNA sequencing to identify cellular dynamics in thyroid cancer.
Conducted integrated multiomics analyses to explore the regulatory networks.
Analyzed the expression patterns of TNFSF12 in different contexts.
Identified a myeloid-centered regulatory network involved in thyroid cancer.
Demonstrated TNFSF12 acts as a context-dependent oncogene.
Provided insights for potential targeted therapy and immunotherapeutic strategies.
Abstract
Our study reveals a myeloid-centered regulatory network in thyroid cancer and highlights TNFSF12 as a context-dependent oncogene, offering novel insights into targeted therapy and immunotherapeutic strategies.