Modeling of Fiber Orientation‐Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model

Key Points

• To explore the relationship between fiber orientation and R1 relaxation in human white matter using the Transient Hydrogen Bond model.
• Utilized the Transient Hydrogen Bond model for analysis.
• Conducted in vivo measurements of R1 relaxation.
• Evaluated the dependence of R1 relaxation on fiber orientation and B0 field.
• The model successfully explains R1 relaxation anisotropy in white matter.
• Demonstrated dependence of R1 relaxation on B0 field variations.