CCL26 ‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Key Points

• The study aims to investigate how tumor-derived exosomes influence endothelial cell behavior through CCL26 under hypoxic conditions.
• Analysis of endothelial secretome modifications
• Exosome isolation from hypoxic tumor environments
• CCL26 level measurement in endothelial cells
• Elevated CCL26 levels in endothelial cells exposed to hypoxic tumor-derived exosomes
• Enhanced tumor-supportive characteristics in endothelial cells
• Increased metastatic progression observed in head and neck cancer models